The human skin is one of the largest epithelial surfaces that can resist external damage and protect against the external environment. The intricate connection between the skin and the gut has been shown by recent research. The homeostasis of gut microbiota impacts skin conditions, while the dysbiosis of microbiota may destroy mucosal immune tolerance and exacerbate skin inflammation. Moreover, the term gut-brain-skin axis has gradually attracted much interest from researchers. Emotional states including stress, depression, and anxiety will change the gut microbiota, trigger the inflammatory response, and negatively impact skin health. Numerous skin issues have been found to be improved by probiotics, including oxidative stress reduction, immune response regulation, and enhanced skin barrier function. This paper attempts to show the significance of gut microbiota on skin disorders and the connection signaling of the gut-brain-skin axis. Additionally, by summarizing the mechanism of probiotic usage in improving skin health, we also provide a mathematical foundation for the use of probiotics in skin health.