As the process of urbanization in our country intensifies, the urban population is gradually increasing, resulting in varying degrees of land use tension and traffic congestion, making urban development encounter great pressure. The development of underground space is particularly important, and underground places with various functions appear constantly. However, the space use feeling and people’s psychological activities of underground buildings are quite different from those above the ground. Therefore, based on the people-oriented principle, the research on the spirit of underground space becomes the focus of our attention. This paper takes Nanjing Museum as the research object, extracts and integrates the elements of place spirit, conducts a questionnaire survey on its place spirit, collects data, refines the dimension of place spirit by using exploratory factors, analyzes the perceived characteristics of the importance and satisfaction of place spirit, finally the paper uses IPA method to evaluate it quantitatively, and gives the corresponding design countermeasures and suggestions.