The identification of haploid induction genes has promoted the advancement of several breeding technologies. Haploid induction genes in wheat, coupled with visual marker, have led to the establishment of a novel in vivo doubled-haploid (DH) technology. When combined with dominant male sterile genes, this innovative DH method presents a promising avenue for high-throughput production of DH lines. Furthermore, the application of haploid induction genes has facilitated the establishment of other innovative breeding technologies, such as HI-Edit and cyto-swapping in creating cytoplasmic male sterility lines, as well as synthetic apomixis. This review summarizes the progress of DH technology in wheat and presents examples of application of haploid induction genes in accelerating breeding practices, aiming to promote the development of these innovative technologies in wheat and enhancing wheat breeding efficiency.