To investigate the clinical effect of concentrated growth factor (CGF) applied in guided bone regeneration (GBR) for severe bone deficiency in the anterior maxilla.

Forty patients with bone defects in the anterior maxilla were chosen to be treated with GBR, 20 patients were treated with CGF applied in GBR as the observation group, and the other 20 patients were treated only with GBR as the control group. The evaluation of wound healing was performed after the operation, and bone augmentation was evaluated half a year after the operation.

The first-stage healing rate of soft tissue wounds in the observation group was 100% and 75% in the control group, and the primary healing rate in the observation group was better than that in the control group (P = 0.017). The changes in bone width of the observation group were (3.70 ± 0.28) mm, and those of the control group were (2.96 ± 0.16) mm. The bone augmentation in the observation group was higher than that in the control group (P = 0.000).

CGF applied in GBR has a good effect on bone augmentation for severe bone deficiency in the anterior maxilla.