To evaluate the treatment effect and drug safety of treating infantile head and neck hemangioma with oral propranolol.

Oral propranolol was applied to 68 infants(male 20 cases, female 48 cases, from 1 to 9-month-old, with an average age of 4. 2 month) with heamngiomas. The daily dose of propranolol was increased from 0. 5 mg / kg at the first day to 1. 0 mg / kg at the second day, and to 2 mg / kg at the third day. The daily dose was given equally every 8 hours. A therapy dose of 2 mg / kg / day was given until 1-year old, and the patients were visited every month. The changes of tumor size, texture, color and adverse effects were monitored. The short-term results were evaluated and adverse effects after medication were observed and managed accordingly by Achauer criterion.

Although side effects were noted in 23 cases (33. 8%), most were mild adverse effects and propranolol therapy was continued after symptomatic treatment. 2 patients (2. 9%) were stopped therapy due to hypotension and abnormal liver function after drug administration. The results were evaluated using Achauer system, scale Ⅰ (poor) in 6 patients (8. 8%), scale Ⅱ (moderate) in 11 patients(16. 2%), scale Ⅲ (good) in 17 patients (25%) and scale Ⅳ (excellent) in 32 patients (47. 1%).

Oral propranolol treatment of infantile hemangioma has elicited high efficacy and tolerance with few expected adverse effects. It might be used as the first-line treatment for infantile head and neck hemangioma.

To investigate the clinical and pathological characteristics of the parotid gland tumor in adolescent for providing clinical evidence for its treatment.

The clinical and pathological data of 31 adolescents (10-19 years old) from Jan. 2003 to Dec. 2011 were retrospectively studied and compared with 516 adult cases at the same time.

38.7%(12/31) of the parotid gland tumors in adolescent were malignant, but only 17%(88/516) in adults. Among the 31 cases, 19 cases were benign tumor (61.3%), 12 cases were malignant tumor (38.7%). Among the benign cases, pleomorphic adenoma was the most common diseases, which accounted for 89.5%(17/19). Mucoepidermoid carcinoma (5/12) was the most common malignancy. All of the 31 cases were treated surgically, and 2 malignant cases were treated combined with postoperative radiotherapy.

The clinical and pathological features of parotid gland tumors in adolescent are different from those in adults, and more attention should be paid to this phenomenon. Operative treatment is the preferred treatment of parotid gland tumor in adolescent, which should be early and thorough. Thus far, there is great dispute on postoperative radiotherapy.