Fluoroquinolones, a group of synthetic antibiotics, are widely used in the prevention and control of livestock diseases. If overused, fluoroquinolones will pose a threat to peoples’ health. Therefore, it is of great significance to establish an efficient detection method for monitoring fluoroquinolones residues in animal-derived food. In this paper, we introduce readers to the types and toxicity of fluoroquinolones, and present a detailed review of recent progress in the development of detection methods for fluoroquinolones residues in animal-derived food. It is expected that this review can provide a reference for the monitoring of fluoroquinolones residues in animal-derived food.

Based on the self-polymerization reaction of dopamine (DA), a polydopamine (PDA) film was formed on the surface of silver nanoparticles (AgNPs) and glassy carbon electrode (GCE), which could result in uniform dispersion of AgNPs on the surface of GCE. As a result, PDA@AgNPs/GCE modified electrode was obtained. The self-polymerization time of DA and the electrochemical test method and conditions for chlorpromazine were investigated and optimized to establish a rapid method for the detection of chlorpromazine based on square wave voltammetry. The modified electrode was characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM). Under the optimal conditions, the oxidation peak current of chlorpromazine on PDA@AgNPs/GCE had a good linear relationship with its concentration in the range of 5.0×10^-8–1.0×10^-5 mol/L (R²=0.991). The detection limit (R_SN=3) was 1.7×10^-8 mol/L. The recoveries of chlorpromazine in spiked pork, chicken and beef samples were 84.9%–88.8%, 79.8%–93.8% and 80.6%–93.9%, respectively. The instrument used in the method was light and portable, and the preparation method of the modified electrode was simple, easy, cheap, and convenient for batch preparation of modified electrodes, and could be used for the rapid detection of chlorpromazine in livestock and poultry meat.