Quorum sensing (QS) is a communication mechanism between bacterial cells that can realize the expression of specific genes through the continuous accumulation of signal molecules. Quorum quenching can hinder the quorum sensing process by inhibiting or interfering with signal molecules, thereby slowing down the spoilage of specific foods and prolonging their shelf life. Therefore, quorum quenching plays a particularly important in food preservation. This article introduces the reader to different quorum sensing systems and the mechanism of quorum quenching. It reveals the great potential of quorum quenching in food preservation, which will provide a theoretical reference for food preservation.