To evaluate the agreement of axial length (AL), anterior chamber parameters, and total cornea power obtained by swept-source optical coherence tomography (SS-OCT)-based and Scheimpflug-based optical biometers in myopic children.

AL, steep keratometry (K), flat K, posterior corneal keratometry (PK), total keratometry (TK), anterior chamber depth (ACD), horizontal corneal diameter (CD), and central corneal thickness (CCT) were obtained using IOL Master 700 and Pentacam AXL. The agreement between the devices was evaluated using intraclass correlation coefficients (ICC), Bland-Altman plots, and astigmatism vector analysis.

Totally 175 myopic children (48.5% male) with a mean age of 10.29±2.14y were enrolled. The ICC and Bland-Altman plots indicated a satisfactory agreement for AL, ACD, and CCT. The mean difference in CD of -0.31±0.30 mm was considered clinically significant (>0.2 mm). Additionally, measurements of K and TK obtained from the IOL Master 700 showed good agreement. Nevertheless, there were clinically significant differences observed in PK, simulated keratometry (simK), total cornea power, and astigmatism (at least 10% of the cases with a difference of >10 degrees in meridian) between the two devices.

The study findings demonstrate a significant difference in K, PK, astigmatism, and CD, indicating that the two optical biometers cannot be considered interchangeable. Therefore, it is recommended to utilize one kind device for follow-up examinations in myopic children.

To evaluate refraction and ocular biological characteristics in children with unilateral congenital ptosis.

In this cross-sectional study, 200 Chinese children (3-15y) with unilateral congenital ptosis were evaluated. Cycloplegic refraction and ocular biological measurements were taken from Oct. 2020 to Aug. 2022.

In patients with congenital ptosis, the prevalence of with-the-rule astigmatism and oblique astigmatism was significantly high. The cornea was flatter in ptotic eyes [K1 (42.37±1.62 vs 42.78±1.51 D), K2 (43.8±1.86 vs 44.2±1.64 D), corneal power (Km; 43.09±1.68 vs 43.49±1.53 D), all P<0.001]. Axial length (AL) was longer in ptotic eyes (22.55 vs 22.51 mm, P=0.012). The white-to-white (WTW) was significantly smaller in ptotic eyes (11.49 vs 11.65 mm, P<0.001). The central corneal thickness (CCT) was greater in ptotic eyes (553.50 vs 545.00 µm, P<0.001). No significant differences were found in anterior chamber depth (AD), lens thickness (LT) and vitreous thickness (VT) between ptotic and fellow eyes (P>0.05). In addition, the incidence of amblyopia in ptosis eyes was 32.0%, which was significantly higher than that in the normal population.

Ptotic eyes have longer AL, flatter, thicker and smaller corneas than fellow eyes. The congenital ptosis increases the risk of amblyopia. The results suggest that regular examinations of refractive status and ocular biological parameters such as AL, are essential for children with unilateral congenital ptosis.