Neuromyelitis optica spectrum disorder (NMOSD) is an idiopathic autoimmune inflammatory disorder which is characterized by central nervous system (CNS) demyelinating. Common symptoms of area postrema clinical syndrome (APS) include intractable hiccup, nausea and vomit which may lead to aspiration pneumonia. In this article, we report a patient with suspicious COVID-19 infection and complicated with NMOSD and aspiration pneumonia. The question still remains that whether 2019-nCoV could infect CNS and cause NMO.