Reconfigurable devices can be used to achieve multiple logic operation and intelligent optical sensing with low power consumption, which is promising candidates for new generation electronic and optoelectronic integrated circuits. However, the versatility is still limited and need to be extended by the device architectures design. Here, we report an asymmetrically gate two-dimensional (2D) van der Waals heterostructure with hybrid dielectric layer SiO₂/hexagonal boron nitride (h-BN), which enable rich function including reconfigurable logic operation and in-sensor information encryption enabled by both volatile and non-volatile optoelectrical modulation. When the partial gate is grounded, the non-volatile light assisted electrostatic doping endowed partially reconfigurable doping between n-type and p-type, which allow the switching of logic XOR and not implication (NIMP). When the global gate is grounded, additionally taking the optical signal as another input signal, logic AND and OR is realized by combined regulation of the light and localized gate voltage. Depending on the high on/off current ratio approaching 10⁵ and reliable & switchable logic gate, in-sensor information encryption and decryption is demonstrated by manipulating the logic output. Hence, these results provide strong extension for current reconfigurable electronic and optoelectronic devices.