Rapidly-advancing microneedle-based bioelectronics integrated with electrical stimulation (ES) therapy exhibit significant potential for improving chronic wound management. Herein, bio-inspired by the serrated structure of bee-stingers, we developed a temperature-sensitive, two-stage microneedle-based electroactive platform (GP-PPy/PLA-MN) featuring rivet-like microstructures that integrates intelligent, precise drug-releasing, ES-transmission, and real-time wound-assessment monitoring for comprehensive chronic wound-management and diagnostic therapy. The bionic-design mechanically anchors the microneedle beneath the skin’s dermis, while GP-PPy/PLA-MN demonstrates versatile therapeutic characteristics, including outstanding biocompatibility, antimicrobial properties, and antimigratory origins. The GP-PPy/PLA-MN enables the sustained release of insulin at body temperature for up to 24 hours through the poly-N-isopropyl acrylamide grafted amidated-gelatin-based thermo-sensitive hydrogel at the needle-tip, thereby providing long-term stable blood glucose control. GP-PPy/PLA-MN indicates its potential as a novel bioelectronics-based patch to record the temperature and humidity during the wound-healing process, realizing significant wound diagnosis and real-time wound assessment, and fundamentally facilitating the therapeutic efficacy by supplying solid data to protect the clinical practice. Extensive in vitro and in vivo studies have demonstrated that GP-PPy/PLA-MN can provide effective ES and sustained drug release, thereby promoting chronic wound healing and increasing the wound healing rate by 20% compared to the control group after 14 days of treatment. This innovative approach combines bioelectronics with intelligent drug delivery and microneedling technology to effectively address the critical challenges of chronic wound management, offering promising prospects for precision diagnostics and therapeutic interventions.

Wound abnormalities such as secondary wound laceration and inflammation are common postoperative health hazards during clinical procedures. The continuous treatment, healing induction, and real-time visualization of wound status and complications, including wound re-tearing, inflammation, and morphology, are key focal points for comprehensive healthcare. Herein, an on-demand quadruple energy dissipative strategy was proposed for the nanoengineering of a physically and chemically synergistic double-layer gelatin-based bio-adhesive (DLGel) by combining a multi-network adhesive layer and a versatile electroactive energy dissipative layer based on contrivable interlocking micro-pillar arrays and crosslinked polymer chains. The subtly multiple energy dissipation designs enable DLGel with robust adhesive strength to omnipotently wet and dynamic tissue, providing a basis for reliable wound closure. DLGel achieves comprehensive wound-healing induction through electrical stimulation and possesses reversible underwater light/thermal adhesion, excellent hemostatic performance, outstanding antimicrobial properties, and self-repair capability. Furthermore, a novel deep-learning strategy is creatively established to respond to mechanical deformation due to wound anomalies. This strategy translates biological information into visual graphics, providing real-time early warning and assessment of postoperative wound-abnormality/-morphology, such as laceration, inflammation, and necrosis. Therefore, DLGel and its associated signal collection and processing protocol enable the integration of reliable wound closure, wound healing, and real-time postoperative wound-status warning and assessment within the unobservable and undetectable “black box” regions in a context of non-clinical comprehensive therapy.

Currently, due to improvements in living standards, people are paying more attention to all-around disease prevention and health care. Self-powered implantable “tissue batteries” integrated with electrochemical materials are essential for disease prevention, diagnosis, treatment, postoperative therapy, and healthcare applications. We propose and define new concepts of “tissue batteries”—self-powered tissue batteries (SPTBs)—are flexible self-powered implantable systems or platforms based on electroactive biomaterials, acting at the interface of biological tissue. Based on the electrical phenomenon of living organisms in life activities, there has been an increased attention to SPTBs for tissue repair promotion. SPTBs take advantages of both the preeminent biocompatibility of biomaterials and the promotion of time-honored electrical stimulation therapy for tissue recovery, which are very promising for human illness treatment. However, studies on clinical applications of SPTBs are impeded by a lack of comprehensive cognitive assessment of SPTBs. Herein, SPTBs for life and health applications are comprehensively reviewed. First, electrochemical materials and their across-the-board applications for several types of SPTBs are introduced and compared with regard to disease prevention, diagnosis, precision therapy, and personalized health monitoring. Then, the potential mechanisms for SPTBs for tissue repair promotion are discussed. Finally, the prospective challenges are summarized and recommendations for future research are provided. This review elucidates on the significance and versatility of SPTBs for various medical applications.