Open Access Protocol Issue
Clinical trial of intrathecal injection of protein polymers for apoplexy: A protocol
Journal of Neurorestoratology 2023, 11 (2): 100052
Published: 14 April 2023

Protein polymers derived from mesenchymal stem cells, especially human umbilical cord mesenchymal stem cells, showed promising potentials in treating ischemic stroke, thanks to the advantages of selective assembly, targeted delivery, efficient repair of damaged tissues, high safety, highly stable chemical properties, and being easy for storage. Herein, we introduced a clinical trial based on protein polymers derived from human umbilical cord mesenchymal stem cells. The main purpose of this clinical study is to preliminarily verify the safety and efficacy of intrathecal administration and application of protein polymers in clinical treatment of ischemic stroke cases. The summary of the program, the research plan, test protein polymer intrathecal injection method, experimental protein polymer management, patient evaluation index, data management and statistical analysis, technical features, trial schedule etc. are detailed described in the article. This clinical study provides information for other clinical trials based on protein polymers and medicines used to treat apoplexy.

Open Access Case Report Issue
Diagnosis and treatment of micro-entrapment syndrome of nerves innervating the face: A report of two cases
Journal of Neurorestoratology 2022, 10 (1): 66-71
Published: 05 March 2022

The term "micro-entrapment syndrome of nerves innervating the face (MESNIF)" is a relatively new concept. It refers to the micro-entrapment of facial nerve (trigeminal nerve and facial nerve) terminals for various reasons, resulting in one-side facial discomfort, subjective sensory abnormalities, or stiffness, and in certain cases, localized micro muscle movement abnormalities and motor disharmony. It is frequently caused by facial paralysis or chronic trigeminal neuritis or injury, and is prevalent in clinical practice. Peripheral facial paralysis affects 60%-70% of people. Both men and women are susceptible to it. It is most common in young and middle-aged women. At the moment, there are two types of therapy options for this disease: nonsurgical treatments and surgical treatments. Among surgical treatments, pulsed radiofrequency has good curative results. This paper describes two typical situations that had good curative effects.

Open Access Letter to the Editor Issue
Tiger face: characteristic manifestations of Meige syndrome
Brain Science Advances 2021, 7 (4): 263-265
Published: 10 January 2022

Meige syndrome is a neurological disorder discovered by Henry Meige, a French neurologist. The initial clinical manifestations are blepharospasm in both eyes and the characteristic facial appearance of tiger face lines. The patient displays an abnormal facial expression. Trauma, psychological, endocrine, and pharmacological factors may play a role in secondary Meige syndrome. Here we describe these clinical signs with pictures.

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