High-pressure electrocatalysis has rapidly evolved into a versatile strategy for overcoming the solubility, mass transport, and kinetic limitations that beset ambient-pressure electrochemical conversions. By increasing the pressure, interfacial concentrations of key reactants such as CO₂, CO, N₂, and NO can be raised by 1 to 2 orders of magnitude, profoundly reshaping surface coverage of intermediates, local pH, and electric double-layer structure. Over the past 5 years, these effects have enabled record-level Faradaic efficiencies and industrially relevant current densities for the synthesis of formate, methane, multicarbon oxygenates, and ammonia. Coupled advances in reactor architecture—from pressure-tolerant H-cells and narrow-gap flow cells to zero-gap membrane electrode assembly stacks—now permit sustained operation at dozens of bar while maintaining energy efficiencies above 40%. Complementary operando spectroscopies capable of withstanding harsh conditions have elucidated pressure-controlled reaction pathways. Our work aims to advance the electrochemical synthesis of fundamental chemicals, positioning high-pressure electrochemical synthesis as a viable and transformative solution.

Great photoelectric properties can herald the high potentials of CsPbBr₃ nanocrystals (NCs) to function as the fluorescent probes for early tumor diagnosis. However, the intrinsic water vulnerability of CsPbBr₃ NCs highly restricts their biomedical applications. To conquer this challenge, we herein introduce a nature inspired "stress-response" method to tightly encapsulate CsPbBr₃ into SiO₂ nano-shells that can dramatically improve the water stability of CsPbBr₃@SiO₂ nanoparticles for over 48 h. We further highlighted the advantageous features of CsPbBr₃@SiO₂ by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability, biocompatibility, and low cytotoxicity. Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis, and can highly anticipate the further in vivo biomedical applications that light up live cells.