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Nano Research 2020, 13(3): 795-801 https://doi.org/10.1007/s12274-020-2697-9
Research Article | Issue | Published: 16 March 2020

Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation

Show Author's Information Wentao Song1,  Yiming Wang1,  Bing Wang2,3,  Yingfang Yao1,2,3( ),  Wenguang Wang2,  Jinhui Wu2,  Qing Shen4,  Wenjun Luo1,2,3,  Zhigang Zou1,2,3,5( )
Eco-materials and Renewable Energy Research Center (ERERC), College of Engneering and Applied Sciences, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Jiangsu Key Laboratory for Nano Technology, National Laboratory of Solid State Microstructures, Department of Physics, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Collaborative Innovation Center of Advanced Microstructures, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Faculty of Informatics and Engineering, The University of Electro-Communications, Tokyo 182-8585, Japan
Macau Institute of Systems Engineering, Macau University of Science and Technology, Macau 999078, China
Keywords:
CsPbBr3 nanocrystals, stress response encapsulation, cancer diagnose
Topics:
BiocompatibilityBiomimetics Bromine compoundsDiagnosisFluorescenceMedical applicationsNanocrystalsPerovskiteProbesSilicaSilica nanoparticlesSiliconSiO2 nanoparticlesTumors
Cite this article:
Song W, Wang Y, Wang B, et al. Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation. Nano Research, 2020, 13(3): 795-801. https://doi.org/10.1007/s12274-020-2697-9
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Abstract Full text Electronic supplementary material About this article

Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals (NCs) to function as the fluorescent probes for early tumor diagnosis. However, the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications. To conquer this challenge, we herein introduce a nature inspired "stress-response" method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h. We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability, biocompatibility, and low cytotoxicity. Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis, and can highly anticipate the further in vivo biomedical applications that light up live cells.


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Electronic supplementary material
About this article

Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation

Show Author's information Wentao Song1, Yiming Wang1, Bing Wang2,3, Yingfang Yao1,2,3( ), Wenguang Wang2, Jinhui Wu2, Qing Shen4, Wenjun Luo1,2,3, Zhigang Zou1,2,3,5( )
Eco-materials and Renewable Energy Research Center (ERERC), College of Engneering and Applied Sciences, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Jiangsu Key Laboratory for Nano Technology, National Laboratory of Solid State Microstructures, Department of Physics, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Collaborative Innovation Center of Advanced Microstructures, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Faculty of Informatics and Engineering, The University of Electro-Communications, Tokyo 182-8585, Japan
Macau Institute of Systems Engineering, Macau University of Science and Technology, Macau 999078, China

Abstract

Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals (NCs) to function as the fluorescent probes for early tumor diagnosis. However, the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications. To conquer this challenge, we herein introduce a nature inspired "stress-response" method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h. We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability, biocompatibility, and low cytotoxicity. Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis, and can highly anticipate the further in vivo biomedical applications that light up live cells.

Keywords: CsPbBr3 nanocrystals, stress response encapsulation, cancer diagnose

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Publication history
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Acknowledgements

Publication history

Received: 28 October 2019
Revised: 01 February 2020
Accepted: 04 February 2020
Published: 16 March 2020
Issue date: March 2020

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020

Acknowledgements

The author thank Professor Peng Wang for experimental assistance in STEM-HAADF measurements. This work was supported primarily by the National Key Research and Development Program of China (No. 2018YFE0208500), the Major Research Plan of the National Natural Science Foundation of China (No. 91963206), the National Natural Science Foundation of China (Nos. U1508202 and 51627810), the Natural Science Foundation of Jiangsu Province (No. SBK2018022120), the open fund of Wuhan National Laboratory for Optoelectronics (No. 2018WNLOKF020), the open fund of Jiangsu Key Laboratory of Electrochemical Energy Storage Technologies (No. EEST2018-1), and the civil aerospace technology preliminary research project of the State Administration of Science, Technology and Industry for National Defense.

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