Malignant tumors remain a leading cause of premature death worldwide, with disproportionately increasing burdens in resource-limited regions. Although immune checkpoint blockade (ICB) has emerged as a transformative cancer therapy, its efficacy is often limited by the immunosuppressive tumor microenvironment (TME). Leveraging iron as the most abundant bioactive transition metal in Earth's crust, we report F-Fe, a complex IV-targeted carbon monoxide-releasing molecule (CORM) that is activated by a clinically approved dental light-curing unit to induce pyroptosis for reprogramming the TME. We developed a bioinspired delivery system named GLEAM to facilitate clinical applications that adhere to tissue surfaces while channeling light into deeper tissue for on-target CO release, simultaneously providing real-time visual feedback for treatment monitoring. Murine oral and breast cancer models validated the therapeutic efficacy, showing significant tumor suppression and TME remodeling. When combined with anti-PD-1 antibody (aPD-1) therapy, it markedly suppressed metastasis, prevented recurrence, and prolonged survival. Our findings suggest that Fe-based small molecules with biomimetic delivery can leverage dental light to boost ICB efficacy, offering a sustainable and translational approach to tumor treatment.

For the first time, chitin microspheres woven from nanowires with multi-scale porous structures were used as an excellent support for a catalyst of ultra-small Pd clusters. The Pd species anchored on the precursor Pre-Pd@chitin were 0.6 nm in average size, while the reduced catalyst Red-Pd@chitin featured ultra-small particles of 1.3 nm in average size. X-ray absorption spectroscopy (XAS) and transmission electron microscopy (TEM) demonstrated that the Pd catalyst in both oxidative and reductive states retained good dispersity and ultra-small clusters. The catalyst was tested for the hydrogenation of p-nitroanisole, exhibiting an excellent initial rate (13× that of commercial Pd/C)and excellent turnover frequency reaching 52, 000 h^-1. Furthermore, the catalyst could be recycled and used more than 10 times with no decay of the catalytic activity, suggesting potential industrial applications.