To investigate the protective effects of Qiji Special Dietary Food on exercise-induced myocardial injury in mice.

An exercise-induced myocardial injury model was established using a treadmill running protocol, and at the same time, the modeled mice were administered Qiji Special Dietary Food via oral gavage, followed by a 4-week treadmill exhaustion test. Serum levels of cardiac troponin T (cTnT), creatine kinase (CK), and lactate dehydrogenase (LDH) were measured. Myocardial tissues were analyzed for superoxide dismutase (SOD) activity and malondialdehyde (MDA) content. Histopathological alterations and ultrastructural changes in myocardial tissue were evaluated using light microscopy and transmission electron microscopy (TEM).

After 4 weeks of exhaustive training, compared to the control group, the model group exhibited significantly elevated serum cTnT, CK, and myocardial MDA levels (P<0.01), along with reduced myocardial SOD activity (P<0.01). Compared to the model group, high-, medium-, and low-dose treatment significantly attenuated the exhaustive exercise-induced increases in serum cTnT level and myocardial MDA content (P<0.01), restoring these indicators to the levels comparable to those of the normal control group (P<0.05). Additionally, all treatment groups had markedly increased myocardial SOD activity, with no significant difference from the normal group. Histopathological and ultrastructural analyses revealed markedly alleviated myocardial damage in the treatment groups, with the medium-dose group exhibiting the most pronounced protective effects.

Qiji Special Dietary Food demonstrates significant protective effects against exercise-induced myocardial injury in mice, which maybe associated with its antioxidant activity and mitigation of oxidative stress.