Oxidative stress is an inherent pathophysiological feature in burn wound healing. Severe burns trigger rapid changes in patients’ conditions, leading to ischemia–reperfusion injury from early fluid resuscitation, neuroendocrine stress, and fluid imbalances, which exacerbate oxidative damage and organ dysfunction. This review highlights the critical role of oxidative stress in post-burn wound healing, its potential to cause cellular and tissue damage, and oxidative stress mechanisms. Antioxidant therapy is recommended as a cost-effective method of modulating inflammation and burn outcome. Preparative measures of successful antioxidant therapy should be developed in improving burn patients’ wound healing.