Gene-editing methods have significantly advanced genetic improvement and variety development in major food crops and have potential to make further major contributions to food security and human health. In this perspective, we analyze publication and patent data related to gene editing in rice (Oryza sativa), maize (Zea mays), soybean (Glycine max), and wheat (Triticum aestivum) from 2013 to 2024. We survey the global research and development landscape, development trends, innovations in biotechnological breeding, and industrial applications of gene-edited crops, with particular attention to traits relevant to nutritional quality and health-related benefits. Our synthesis provides a reference for future research and industrialization of gene-edited crops.