For the first time, a general ¹H-quantitative nuclear magnetic resonance spectrometry (¹H-qNMR) method for the simultaneous quantification of heroin hydrochloride, cocaine, cocaine hydrochloride, and 7 adulterants was established after the discussion of some key quantitative parameters. According to the solubility and stability of heroin hydrochloride, cocaine, and cocaine hydrochloride in different deuterated solvents, and the spectra comparison of seized samples and reference materials, dimethylsulfoxide-d6 was selected as the solvent, and 1,3,5-trimethoxybenzene was selected as the internal standard. The signals at δ_H 6.09 ppm for internal standard 1,3,5-trimethoxybenzene; at δ_H 6.87, 6.71, 2.24 ppm for heroin hydrochloride; at δ_H 7.90, 7.64, 5.12, 3.61 ppm for cocaine; and at δ_H 7.88, 5.49, 2.79 ppm for cocaine hydrochloride were selected as quantitative peaks．The established ¹H-qNMR method was applied for the quantification of 168 seized samples, the content of heroin and cocaine were basically consistent with the results of High-performance liquid chromatography. This method is simple, fast, accurate, does not require standard samples, and shows good tolerance and high reproducibility. It can provide new ideas for the quantification and profiling analysis of seized drug samples.