Van der Waals (vdW) crystals supporting in-plane anisotropic hyperbolic phonon polaritons (HPhPs) provide a promising route toward mid-infrared (MIR) and terahertz (THz) nanophotonics by enabling deep-subwavelength confinement, low-loss propagation, and directional control of light within the crystal plane. Although such anisotropic HPhPs have been reported in a few vdW crystals, most studies have relied on bulk crystals or mechanically exfoliated flakes, which limits scalability and compatibility with device fabrication. At present, α-MoO₃ is essentially the only vdW material available as large-area nanoflakes for fabrication-ready anisotropic polaritonic structures. Here, we demonstrate the scalable physical vapor deposition (PVD) growth of free-standing, monocrystalline α-V₂O₅ nanoflakes with lateral dimensions up to hundreds of micrometers and thicknesses down to a few nanometers. Using infrared nano-imaging together with theoretical analysis, we uncover low-loss in-plane anisotropic HPhPs in α-V₂O₅ with strong confinement (λ₀/λ ≈ 100), ultraslow group velocities (~3×10^-4c), and lifetimes up to 9 ps. We further show that patterned microdisk cavities enable geometry-defined shaping of the polaritonic near field, allowing tailored in-plane electromagnetic confinement. Our results establish α-V₂O₅ as a large-area, monocrystalline, fabrication-ready vdW material for low-loss anisotropic polaritonics, and expand the materials basis for scalable infrared flat photonics and future on-chip polaritonic devices.