The Weihe River is a primary tributary of the Yellow River, rich in cultural resources from major sites within its basin. However, the development of cultural industries in these major sites varies greatly, with a pronounced polarization and overall lagging behind. This article analyzes the distribution of cultural resources and the current development status of cultural industry clusters in the Weihe River Basin through methods such as data statistical analysis, spatial analysis, and visualization analysis. It studies the problems of insufficient systematic protection of large sites in the region, low level of development of cultural industries in large sites, and uneven development of cultural industry clusters in large sites. Combined with national spatial planning, it proposes ideas for adjusting the protection zoning of large sites in the Weihe River Basin, regional collaborative development planning, and overall linkage planning mode. It attempts to explore and provide support for the overall protection of large sites, ecological environment protection, and high-quality development in the Weihe River Basin.