A refrigerant is an essential working fluid in a vapor-compression refrigeration cycle. Hydrofluorocarbons are currently used as refrigerants in refrigeration, air-conditioning, and heat pump systems and are potent greenhouse gases. Thus, replacement refrigerants with high thermal performances and low environmental impacts must be identified. This paper presents a comprehensive review of the refrigerants in different vapor-compression cycle applications covering the temperature range from -100 ℃ to 200 ℃. The most promising low-GWP alternative is proposed. Moreover, five refrigerants, including HFO-1234yf, HFO-1234ze(E), HFO-1234ze(Z), HCFO-1233zd(E), and HFO-1336mzz(Z), for application in vapor compression equipment, are summarized.