To construct a more durable long-life asphalt pavement with semi-rigid base, we combine different technical characteristics of long-life asphalt pavements reported at home and abroad. Different interlayer bonding conditions and moduli of the bottom sublayer are considered to analyze the mechanical-state differences among long-life asphalt pavements with semi-rigid base. The following two issues are discussed: fatigue failure in the surface layer and coordination between anti-rutting and anti-fatigue characteristics. Four-point bending fatigue tests are then used at various temperatures and loading modes to evaluate the anti-fatigue characteristics of high-modulus asphalt concretes. The index of accumulative dissipated energy is adopted to compare with materials in the upper sublayer. Analysis results indicate that the application of high-modulus asphalt concrete in long-life asphalt pavement with semi-rigid base can improve anti-rutting and anti-fatigue characteristics and has some rationality.