Propane (R290) is a potential refrigerant substitute for household air conditioners. However, its flammability limits its application. In this study, the flammability limits of R290, 2,3,3,3-tetrafluoropropene (R1234yf), trans-1,3,3,3-tetrafluoropropene (R1234ze(E)), R1234ze(E)/R290, and R1234yf/R290 were determined according to the ASHRAE 34-2022 standard. The effects of R1234yf and R1234ze (E) on the flammability of R290 were analyzed, and the inhibiting abilities of R1234yf, R1234ze(E), R32, R13I1 and R134a on the flammability of R290 were compared. In addition, the refrigeration cycle performance of R290 mixtures with different compositions was simulated. The results showed that both R1234yf and R1234ze(E) exhibited limited flame inhibition capabilities for R290. When the mass fractions of R1234yf and R1234ze(E) reached 80%, the lower flammability limit of the mixture increased by approximately 1.0%. The experimental data were correlated using the Le Chatelier model, which resulted in an average absolute deviation of 0.57% between the calculated and experimental results. Compared with R290, the energy efficiency ratio of the two refrigerants and R290 mixture decreased by less than 1%, and the volumetric cooling capacity increased by less than 0.4%. The flame inhibition effect of the refrigerant on R290 decreased in the following order: R13I1>R134a>R32>R1234ze(E)/R1234yf.