The environment around us naturally represents number of its components in fractal structures. Some fractal patterns are also artificially simulated using real life mathematical systems. In this paper, we use the fractal operator combined to the fractional operator with both exponential and Mittag-leffler laws to analyze and solve generalized three-dimensional systems related to real life phenomena. Numerical solutions are provided in each case and applications to some related systems are given. Numerical simulations show the existence of the models' initial three-dimensional structure followed by its self- replication in fractal structure mathematically produced. The whole dynamics are also impacted by the fractional part of the operator as the derivative order changes.