Transportation infrastructure is difficult to manage and maintain during the operation period, because they are widely distributed and involves many points. In view of this problem, the current situation of structural health monitoring of transportation infrastructure is introduced, a monitoring system architecture of regional transportation infrastructure group is proposed, the functional requirements of the platform is analyzed, and the key technologies such as data volume estimation, data flow control, structured storage, automatic operation and maintenance are studied. On this basis, Wuyuan Highway Integrated Platform is designed to realize the integrated monitoring of bridge and slope group in Wuyuan County. The application results show that the platform has complete and practical function, stable performance and reliable operation, which reduces the difficulty of management and maintenance of regional transportation infrastructure and improves the work efficiency.