Publications
Sort:
Open Access Research Article Issue
Dynamical analysis for an age-structured hepatitis B infection model with latency and HBV DNA-containing capsids
Electronic Research Archive 2026, 34(5): 3251-3276
Published: 15 May 2026
Abstract PDF (588.5 KB) Collect
Downloads:0

In this paper, we propose an HBV infection model with DNA-containing capsids and age structures in both the latent and infected compartments. We derive the basic reproduction number 0 and prove, via Lyapunov functions and LaSalle's invariance principle, that the global dynamics are fully determined by 0 : viral clearance when 0 < 1 and endemic persistence when 0 > 1. The local stability of each equilibrium is rigorously established by employing linearization techniques and analyzing the associated characteristic equations. Compared to the previous age-structured HBV models without a latent compartment, our results reveal the significant impact of latent age structure on infection thresholds and disease progression.

Total 1