To study the effect of iron tailings content on the workability, mechanical properties and durability of road concrete, different proportions of iron tailings were used to replace natural sand as fine aggregate to prepare road concrete. The workability, compressive strength, flexural tensile strength, splitting tensile strength, dry shrinkage, impermeability and wear resistance of concrete were tested. The results showed that the workability of concrete mixed with iron tailings was good, which could fully meet the construction requirements. The 28-d flexural tensile strength of iron tailings concrete exceeds the designed standard value of 4.0 MPa, and the maximum is 5.9 MPa. With the increase of the dosage of iron tailing sand, the dry shrinkage strain and wear amount of concrete gradually increased and the water penetration depth decreased. The introduction of iron tailings will improve the impermeability and wear resistance of concrete, but it will increase the dry shrinkage. Therefore, the content of iron tail sand should not be too large. Under the condition of ensuring the performance of concrete, the content of iron tailings in fine aggregates should be controlled at about 50%.