Cultured meat, as a novel food, differs significantly from conventional meat in its production process, necessitating targeted food safety regulation. However, as China's current regulatory framework and system for food safety are not fully applicable to cultured meat, there is an urgent need to establish a dedicated food safety regulatory framework and institutional system for this novel product. This paper begins by identifying food safety risks associated with cultured meat. Drawing on the experiences and challenges of other jurisdictions in regulating cultured meat, it examines, from the perspective of systemic risk governance, how to construct a food safety regulatory framework for cultured meat that suits China's national conditions, guided by the core principles of safety and controllability, industrial compatibility, and public trust. This study aims to provide research insights and implications for improving China's regulatory policies and promoting the healthy development of the cultured meat industry.