In this paper, we introduce a new class of generalized close-to-convex functions, which are defined by quasi-subordination relationship. The integral expression, the estimation of the first two terms and the Fekete-Szegö problem of functions belonging to the class are obtained. Our results extend and unify previous work on starlike, convex, and close-to-convex functions under quasi-subordination. Examples are provided to demonstrate sharpness.