"Pan-nodules" refer to the comorbidity phenomenon in which multiple organ nodules, such as thyroid nodules, breast nodules, and uterine fibroids, occur simultaneously or successively, which is commonly observed in women of childbearing age. The specialized diagnostic and treatment model of Western medicine often fails to account for nodules across multiple systems, leading to treatment plans that are prone to conflict. Moreover, benign nodules still have the risk of malignancy, and long-term follow-up and surgical intervention can lead to increased physical and mental burdens on patients. The difficulty in its treatment lies in the widespread distribution of nodules, the complex pathogenesis, and the tendency to recur. Traditional Chinese medicine classifies them as distinct diseases and treats them separately in different specialties. Based on the "qi circular flow" theory of HUANG Yuanyu, a renowned physician of the Qing Dynasty, this study proposes that the core etiology and pathogenesis of "pan-nodules" are the deficiency and decline of the spleen earth in the middle jiao, the dysfunction of the pivot, the disorder of the ascending and descending of the liver and lungs, and the obstruction of the meridians with phlegm turbidity and blood stasis along with qi, resulting in visible nodules. The clinical classification of "pan-nodules" is primarily characterized by spleen deficiency with phlegm-dampness, liver depression with qi stagnation, and the interplay of phlegm and blood stasis. Based on this, a "different diseases treated in the same way" diagnosis and treatment system was proposed, with the fundamental principle of "turning the pivot and restoring its circulation." The priority is to increase the middle to eliminate the source of phlegm, then soothe the wood and consolidate the metal to smooth the flow of qi, and finally dissolve phlegm and remove blood stasis to disperse the nodules. Clinical practice should follow the menstrual cycle of women and carefully weigh the selection of blood-activating drugs for patients of childbearing age. It aims to systematically regulate the overall qi movement, improve the environment for the growth of nodules from the source, provide a systematic approach for preventing and treating "pan-nodules" in traditional Chinese medicine, avoid surgical intervention and recurrence risks, and achieve the clinical goal of "preventing the progression of existing diseases and preventing diseases before they occur."

This study examined the pathogenesis and treatment of obese and non-obese polycystic ovary syndrome based on the theory of dynamic and static in traditional Chinese medicine. The pathogenesis of this disease involves spleen and kidney deficiency, liver qi stagnation, qi disorder, water-dampness accumulation, phlegm retention, obstruction of the thoroughfare and conception channels, and impaired ovulation, resulting in irregular menstrual cycles. Clinically, the pathogenesis of patients with obesity and those of normal weight differs. In patients with obesity, phlegm-dampness stagnation predominates and is considered "static." In non-obese patients, the internal movement of thunder and fire is a key pathogenic factor, and the pathogenesis is considered "dynamic." Therefore, the disease demonstrates both dynamic and static characteristics. Patients with obesity are characterized by phlegm accumulation resulting from spleen and kidney yang deficiency and phlegm stagnation. Patients with normal weight are characterized by emotional depression, reflecting liver qi depression and thunder fire delusion. Treatment should incorporate syndrome differentiation based on body constitution, allowing for an understanding of the interaction between dynamic and static aspects. For the obese type, therapy should focus on warming and tonifying the spleen and kidney, supporting fire and yang, warming water and dampness, eliminating uterine fat, facilitating ovulation, and promoting pregnancy. For the non-obese type, treatment should emphasize nourishing and softening the liver for regulation, supplementing the kidneys and spleen, and tonification to subdue thunder and fire and dredge qi and blood. By distinguishing the dynamic and static features of pathogenesis and clinical presentation between the two types, a dynamic and static syndrome differentiation and treatment system for gynecological diseases was established, providing insights for the clinical classification and treatment of polycystic ovary syndrome.