Deep learning (DL) techniques, which do not need complex pre-processing and feature analysis, are used in many areas of medicine and achieve promising results. On the other hand, in medical studies, a limited dataset decreases the abstraction ability of the DL model. In this context, we aimed to produce synthetic brain images including three tumor types (glioma, meningioma, and pituitary), unlike traditional data augmentation methods, and classify them with DL. This study proposes a tumor classification model consisting of a Dense Convolutional Network (DenseNet121)-based DL model to prevent forgetting problems in deep networks and delay information flow between layers. By comparing models trained on two different datasets, we demonstrated the effect of synthetic images generated by Cycle Generative Adversarial Network (CycleGAN) on the generalization of DL. One model is trained only on the original dataset, while the other is trained on the combined dataset of synthetic and original images. Synthetic data generated by CycleGAN improved the best accuracy values for glioma, meningioma, and pituitary tumor classes from 0.9633, 0.9569, and 0.9904 to 0.9968, 0.9920, and 0.9952, respectively. The developed model using synthetic data obtained a higher accuracy value than the related studies in the literature. Additionally, except for pixel-level and affine transform data augmentation, synthetic data has been generated in the figshare brain dataset for the first time.

Medical image steganography aims to increase data security by concealing patient-personal information as well as diagnostic and therapeutic data in the spatial or frequency domain of radiological images. On the other hand, the discipline of image steganalysis generally provides a classification based on whether an image has hidden data or not. Inspired by previous studies on image steganalysis, this study proposes a deep ensemble learning model for medical image steganalysis to detect malicious hidden data in medical images and develop medical image steganography methods aimed at securing personal information. With this purpose in mind, a dataset containing brain Magnetic Resonance (MR) images of healthy individuals and epileptic patients was built. Spatial Version of the Universal Wavelet Relative Distortion (S-UNIWARD), Highly Undetectable Stego (HUGO), and Minimizing the Power of Optimal Detector (MIPOD) techniques used in spatial image steganalysis were adapted to the problem, and various payloads of confidential data were hidden in medical images. The architectures of medical image steganalysis networks were transferred separately from eleven Dense Convolutional Network (DenseNet), Residual Neural Network (ResNet), and Inception-based models. The steganalysis outputs of these networks were determined by assembling models separately for each spatial embedding method with different payload ratios. The study demonstrated the success of pre-trained ResNet, DenseNet, and Inception models in the cover-stego mismatch scenario for each hiding technique with different payloads. Due to the high detection accuracy achieved, the proposed model has the potential to lead to the development of novel medical image steganography algorithms that existing deep learning-based steganalysis methods cannot detect. The experiments and the evaluations clearly proved this attempt.