With the ongoing societal development and changes in lifestyle, the incidence of cardiovascular diseases continues to rise. Although the most effective means of preventing atherosclerotic cardiovascular disease, heart failure, and atrial fibrillation is the lifelong promotion of a healthy lifestyle, pharmacological treatment plays a critical role in the comprehensive management of cardiovascular diseases, with an increasing demand for effective drug management. Effective medication management aids in controlling disease progression, reducing the occurrence of complications, and improving patients' quality of life. Therefore, understanding and mastering the importance of drug toxicity and prescription review in the management of cardiovascular diseases is crucial. Moreover, outpatient time plays a pivotal role in the treatment and recovery of patients. Through appropriate medication management and outpatient practices, better patient management and personalized medical services can be achieved. This paper will focus on discussing the significance of drug toxicity and prescription review in the context of cardiovascular disease management.