On the background of Jiaoding Tunnel of Zhaole expressway in Yunnan, the issue of the compressional deformation of the gently dipping layered tunnel surrounding rock under high in-situ stress was addressed. The initial in-situ stress field was inverted through the hydraulic fracturing tests at the floor of the excavated tunnel. Subsequently, the compressional deformation of the surrounding rock was forecasted and analyzed using the strength-stress ratio-based deformation grading standard. Finally, the control measures of the compressional deformation of the deep-buried gently dipping layered surrounding rock were discussed on account of the deformation and failure characteristics of the surrounding rock. The results indicate that the horizontal principal stress and vertical stress both increase linearly with the depth within the measuring depth range. The maximum horizontal lateral pressure coefficient is 1.52~1.80, while the minimum horizontal lateral pressure coefficient is 0.91~1.10. The horizontal stress is dominant in the engineering area, and the maximum horizontal principal stress orientation is NW294°, which is the same as the principal compressive stress direction of the regional tectonic stress field. The strength-stress ratios of the surrounding rock in the testing section are all less than 4, which implies that the initial in-situ stress belongs to the extremely high stress state. The calculation results of strength-stress ratio show that the deformation grade of the surrounding rock should be mainly the slight (Level-Ⅰ) to medium (Level-Ⅱ) level. However, the deformation grade might well be the strong level (Level-Ⅲ), considering the development of the gently dipping layered joints and the exiting of some extremely broken surrounding rocks. The double-layered initial support and grouting reinforcement can effectively reduce the settlement of the arch crown and the uplift of the arch bottom.