In order to explore the hydraulic fracturing and fracture propagation law of glauberite, the true triaxial fracturing simulation device in the laboratory is used to explore the fracture propagation law of glauberite hydraulic fracturing under different in-situ stress and different water temperature. At the same time, the simulation software is used to analyze the influence of in-situ stress difference and multi well fracturing on hydraulic fracturing fracture propagation. The results show that: Under the condition of low stress difference, the fracture can form a more complex fracture network near the fractured well, while under the condition of high stress difference, the fracture will expand further, but the fracture geometry is relatively single. Comparing the hydraulic fracturing curves of glauberite under different water temperatures, it is found that with the higher temperature, the crack initiation pressure of glauberite is smaller, and the pressure fluctuation in the crack propagation stage is more obvious. The analysis is related to the dissolution of glauberite fracture boundary. Through numerical simulation, it is found that during multi well fracturing, the hydraulic fracturing fracture is easy to deflect due to the change of local stress. The research results can provide practical engineering guiding for the fluid mining of glauberite.