In order to investigate the settlement characteristics of piled raft foundation in layered clayey ground, based on the practical analysis model of piled raft foundation considering the interactions of pile-raft-soil, the settlement of piled raft foundation in typical double-layer clayey ground is analyzed for an example. The influences of 11 different conditions, including the ultimate bearing capacity of the natural ground, the depth of upper and lower layers and the corresponding strength of the soil, the ultimate bearing capacity of the pile shaft and pile end, the size of the pile foundation and the configuration parameters on the settlement characteristics of the piled raft foundation are analyzed via MATLAB programs. Based on the parametric analysis results, a normalized settlement analysis model for piled raft foundation is proposed, which takes into account the influence of the safety factor of the piled raft foundation. By comparing and analyzing the on-site measured data with a series of pile raft foundation engineering examples, the reliability of the proposed normalized model for pile raft foundation was verified. As the design safety factor increases, the discreteness between the calculated results and values gradually decreases. The proposed normalized settlement model can provide a reference for the analysis of piled raft foundation for the engineers.