Low permeability coal seam is characterized by broken coal body, high gas content inside the coal seam, high pressure, and difficult to escape, leading to problems such as imperfect monitoring and warning system of protruding danger and single warning index. This paper puts forward the theoretical assumption of the disaster caused by the protruding center body in digging face based on the theory of comprehensive role hypothesis and the principle of superposition of dynamic and static loads, and accordingly constructs a prediction model of the protruding center body, and researches the multi-parameter monitoring and early-warning technology. Taking the main and secondary roadway excavation in the north third mining area of the north wing of the 8# coal seam in a mine in Yangquan mining area as the engineering background, a study on the relationship between the prediction of protruding danger of the center body of the excavation face and the response of multi-parameter monitoring was carried out by using the methods of on-site test and theoretical analysis, and the results show that: The breeding and development of the outburst center body in the structural area of the North Three Lane are significant. The changing trend of microseismic energy response and K₁ value during excavation is similar, which verifies the feasibility of using microseismic to predict the outburst danger of the center body. The microseismic event, bolt stress, excavation speed and K₁ value are positively correlated with the outburst risk of the center body. The research results are of great significance in revealing the disaster mechanism of coal and gas outburst in low permeability coal seam and to improve the effectiveness of disaster monitoring and prevention.