The nutritional stability of a commercial formula for special medical purposes intended for preterm/low birth weight infants was evaluated during 6 months of accelerated storage at (37 ± 2) ℃ and relative humidity of (75 ± 5)%. The results showed that 19.12% of folic acid in the formula was lost after 2 months, 14.52% of biotin, 24.68% of iodine and 28.12% of selenium were lost after 3 months, and 13.47% of chlorine was lost after 6 months. The loss rate of choline (21.85%) was the highest during accelerated storage. To sum up, the nutrients in the formula were relatively stable, and their levels met the requirements of the Chinese national food safety and labeling standards.