This article discusses seven categories of climate and sustainability innovations, differentiating between transformative and incremental ones, and proposes a systemic innovation framework that envisions the transformative climate and sustainability innovations needed. The framework reframes societal innovations: (i) from reactive, problem-solving, sector-based with technology neutrality, to proactive, vision-driven, need-based with products and services neutrality; (ii) from fragmented to integrated, with the combination of innovative technologies, policies, financial instruments, business models and cooperative approaches, products of the creative industry, and the educative system; and (iii) from closed to open ecosystem with radical collaboration. It also emphasizes mental transformations including metacognitive reframing as well as caring, sharing, and daring leadership.