Based on the water cycle model of distributed architecture, the Chuhe River Basin was divided into hydrological characteristic units such as the slope of the hilly area, the slope of the plain area, the river channel of the hilly area, the river channel of the plain area, the polder area, and the sluice dam project. The Xin’anjiang hydrological model was constructed in the hilly area; the hydrological model and the one-dimensional hydrodynamic model were constructed in the plain area; the flood drainage model was built in the polder area, and the project dispatching model was constructed for the sluice dam project. All models were coupled into an integrated flood control and drainage model that could fully generalize each natural entity element in the Chuhe River Basin. The accuracy and reliability of the model were verified through the flood processes of typical stations in the hilly and plain areas during the flood years (2016 and 2020). The results show that the integrated model can reproduce the flood processes in the basin in 2016 and 2020 quite well, and both the calibration and verification results reach Grade A accuracy.