The bad taste of the drug will seriously affect the patients' medication compliance, after the mesoporous molecular sieve is loaded with the drug, it enters the channel, the amount of drug in contact with the taste buds was significantly reduced, as well as the release rate of the drug, so that the bitterness is greatly reduced. In this paper, MCM-41 molecular sieve (MCM-41), MCM-48 molecular sieve (MCM-48) and hollow mesoporous molecular sieve (HMSS) were used as carriers to mask cetirizine for the first time. At the same time, they were compared with aspartame and β-cyclodextrin — commonly used taste masking agents, and the drug-loaded complexes were characterized and analyzed by X-ray diffraction and Fourier transform infrared spectroscopy. The results showed that except aspartame was only physically mixed, the other four materials were successfully adsorbed or included in the drug. Among them, HMSS has a drug loading of up to 50%, and the bitter taste of the drug is not obvious after drug loading. Its taste masking effect is obviously better than other materials, and it is expected to become a new type of high-efficiency taste masking agent.