To provide a reference for the diagnosis and treatment of mucoepidermoid carcinoma arising in Warthin's tumor of the lip by investigating the diagnosis, treatment and prognosis of the disease.

A case of mucoepidermoid carcinoma arising in Warthin's tumor of lip was reported, including the clinical manifestation, treatment, pathological characteristics and prognosis. The related literature was also reviewed and analyzed.

A painless mass on the left lip lasting more than one month was found. Resection of the left lip was performed. Pathological examination showed that the tumor was a hybridoma composed of mucoepidermoid carcinoma and Warthin's tumor. There was no recurrence or distant metastasis after 34 months. To date, this type of disease has been rarely reported. After thorough resection, the prognosis and survival rate are promising in most cases, with no recurrence or metastasis.

Mucoepidermoid carcinoma in Warthin's tumor of the lip is rare. Clinical manifestations, imaging features and histological examination are useful when diagnosing the disease. Thorough resection will reduce the risk of disease recurrence.