It is difficult to avoid the shedding of brackets during orthodontic treatment, which may not only affect the orthodontic therapeutic effect but also prolong the orthodontic treatment duration. Sodium hypochlorite is a commonly used root canal irrigation agent in oral medicine and is seldom used in orthodontic treatment. Sodium hypochlorite on the enamel surface can strengthen the effect of etching by deproteinization to improve adhesion, which could reduce the probability of bracket shedding during orthodontic treatment. Therefore, this article reviews the effects of sodium hypochlorite on enamel.