To investigate the association between interleukin-6 -572 gene polymorphism and aggressive periodontitis.

A case-control study involved 83 patients with aggressive periodontitis (AgP) and 69 health controls was held, and the genotype and allele distributions of interleukin-6 -572 gene polymorphism were analyzed by PCR-RFLP.

There was statistically significant differences in the genotype distribution by the chi-square test in the two groups (χ² = 13.710, P＝0.001). The distribution of allele frequencies in AgP group was statistically different (χ²＝13.213, P < 0.001) from the healthy control group, and the OR for the G allele is 2.988 (95%CI: 1.634-5.465) when compared with the C allele.

IL-6 -572 gene polymorphism is associated with the susceptibility to AgP in Chinese Han population of Guangdong, and the IL-6 -572 G allele might be a risk factor of the genetic susceptibility to AgP.