To study the protective effect of baicalin on oxidative stress- induced gingival epithelial cell apoptosisand its mechanism.

H₂O₂ was employed to form the oxidative stress - induced gingival epithelial cells apoptotic model, with the intervention of baicalin. The cell proliferation rate, cell apoptosis level, the protein expression of protein kinase B (Akt) and glycogen synthase kinase3β (GSK3β) were investigated respectively.

Baicalin could effectively alleviate oxidative stress-induced inhibition of gingival epithelial cell proliferation and alleviate apoptosis; and it could promote the phosphorylation of Akt-GSK3β signaling pathway.

Baicalin has a significant protective effect on oxidative stress-induced apoptosis of gingival epithelial cells, which may be related to the regulation of Akt-GSK3β signal pathway.