To explore the relationship between periodontitis and preeclampsia (PE) using Meta-analysis method.

The EMBASE, PubMed, CNKI, WanFang and CBM databases were searched up to Oct. 31, 2015, and the relevant references of the included studies were also retrieved manually. The literatures were screened according to the inclusion and exclusion criterias by 2 reviewers independently. The methodology quality was evaluated after data abstraction. RevMan 5.3 software was used for Meta-analyses.

13 studies consist of 12 case-control studies and 1 cohort study were included. A total of 5744 patients were involved, with 1248 preeclampsia (PE) patients and 4496 non PE patients. Meta-analysis showed that periodontitis increased the risk of PE with 2.67 times (OR =2.67, 95%CI = 1.56-4.57, P＜0.001). 3 subgroups of periodontitis were defined by pocket probing depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP), or by PPD with BOP, or by PPD. 3 subgroup analysis all revealed periodontitis was a risk factor, and the OR values were 2.91(95%CI = 2.05-4.11, P＜0.001), 2.33(95%CI = 1.28-4.26, P = 0.006) and 2.8(95%CI = 1.11-7.09, P = 0.03) respectively. Sensitivity analysis showed the results was stable and no publication bias was detected.

Periodontitis is a significant risk factor in PE according to this Meta analysis.