To explore the reliability of liquid nitrogen cryotherapy for infant lip mucosa venous malformations.

A retrospective review of 57 pediatric patients with venous malformations involving the lips who underwent liquid nitrogen cryotherapy was enrolled in. Among them, 35 patients were males and 22 patients were females; the age of the patients ranged from 3 to 21 months (average 7.4 months). Photographs were taken preoperatively, immediately postoperatively and one month postoperatively. Following up period was 2-16 months and the outcome was assessed.

71.9% cases were completely effective, 19.3% cases were mostly effective, 8.8% cases were partially effective. No cases showed the anesthesia complications.

Liquid nitrogen cryotherapy is an effective, simple and safe treatment for lip mucous venous malformations.