Eye health has become an important part of national health. With the improvement of public health conditions, visual fatigue has become a focus of attention in eye health. In this context, functional foods have played a key role in maintaining visual fatigue. However, there are challenges in evaluating the efficacy of functional foods in relieving visual fatigue, including a lack of data from animal experiments and the subjectivity of human feeding trials. This paper analyzes the current development status of functional foods for eye health, the various symptoms of visual fatigue, and their association with visual organ. It explores the significant advantages of 3D tissue-engineered organoid technology in simulating the structure and function of the eye, and its potential application in establishing visual fatigue models and exploring the mechanisms of nutrient interventions. Finally, based on organoid technology and existing technical bottlenecks combined with the current policy orientation, new suggestions are made for the evaluation system for and efficacy claims on eye health-related functional foods. This article provides a new research direction for developing more effective eye health-protecting functional foods and highlights the important role of organoid technology in driving the development of eye health-protecting functional foods.

With the continuous improvement of the evaluation system for health food technology, the existing evaluation methods are no longer able to meet the needs of future development. Therefore, it is particularly important to develop a more comprehensive and accurate evaluation system that combines advanced technological means with traditional evaluation models. Organoid technology, as a new biological means, can simulate the structure and function of human organs more realistically, improve the accuracy and reliability of experiments, and reduce the need for animal experiments. This paper explores the potential application of 3D organoid technology in health food research from the perspectives of toxicological evaluation, the absorption and metabolism of functional factors, the research and development of health foods for special populations, and the development of new evaluation models for functionalities. It also puts forward new considerations on the development direction of health food evaluation system. The aim is to provide a more accurate and physiologically relevant technical platform for the evaluation system of health foods, so as to promote the scientific research and development and strict supervision of health foods.