Towards the demand of edible emulsion-type ointment food and the problems of high energy consumption and cumbersome operation of the traditional preparation method of emulsion, a novel effervescent paste dosage form with fluidity and rapid dispersion was designed in this study. Astaxanthin (AST) effervescent paste was prepared with AST paste as model, tartaric acid and sodium bicarbonate as disintegrants, polyethylene glycol as paste matrix, Tween 80, soybean lecithin and gum arabic as compound emulsifiers. By measuring the key parameters such as particle size, PDI and zeta potential, the process optimization and characterization of the emulsion prepared by AST effervescent paste were carried out. The results showed that the optimal composition ratio of the effervescent paste was 55.00% disintegrant, 3.16% AST paste, 12.63% corn oil, 1.43% soybean lecithin, 4.30% gum arabic, 11.48% Tween 80 and 12.00% polyethylene glycol. The disintegration time of AST effervescent paste was 315.33 s. The particle size, PDI and zeta potential of AST emulsion were 87.82 nm, 0.101 and -44.83 mV, respectively. The droplets of the emulsion were spherical and uniformly distributed. AST emulsion showed a good performance in pH, ionic strength (NaCl), heat resistance, freeze-thaw and centrifugal stability, and no flocculation and demulsification occurred after treatment. Our findings proved that the effervescent paste can obtain stable emulsion by rapid effervescence, which laid a theoretical foundation for the research and development of novel paste products based on effervescent paste technology.
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To design and synthesize dialdoxylose, a glutaraldehyde analogue which is expected to have a low toxicity, and to characterize its performance in crosslinking chitosan in 1% acetic acid solution.
Dialdoxylose was obtained by sodium periodate oxidation and deprotection of monoacetone glucose and used to form crosslinked chitosan gels. The gel strength, fluid properties, water activity and thermal stability of chitosan gels were analyzed by texture profile analysis (TPA), low field-nuclear magnetic resonance (NMR) spectroscopy and differential scanning calorimetry (DSC).
It was found that dialdoxylose exhibited two structures in water, (α,β) and (β,β), with a ratio of 44.4:65.6. The hardness, viscosity and water-holding capacity of the chitosan gel crosslinked with 0.002 g/mL dialdoxylose were highest.
Dialdoxylose has an obvious crosslinking effect on chitosan, which is greatly affected by its concentration. The results of this study are of theoretical guiding significance for the development of new low-toxicity small-molecule crosslinking agents.
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