To solve the problems of poor mechanical properties of high organic mudflat marine sludge, and unsatisfactory curing effect and high energy consumption of traditional cementitious materials such as cement, comparative tests on curing effects of cement-based curing agents and new mineral based curing agents with different formula systems under different curing conditions are carried out based on the specific project. By analyzing and comparing the growth patterns of unconfined compression strength of different types of solidified specimens, the applicability of two types of curing agent materials to the solidification of high organic mudflat sludge is discussed, and then the solidification mechanism analysis and engineering application practice is further conducted, so as to elect the short age, high strength, environment-friendly curing agent which is suitable for the solidification of high organic mudflat sludge. The results show that the new type of SS-W-S mineral based curing agent can agglomerate the fine particles in the sludge and form a stable skeleton structure through a series of functions such as wrapping, bonding and anchoring of hydration products, so that the solidified sludge can finally become an integral structure with certain strength and stability, which can effectively replace the traditional cement-based curing agent, and realize the early-strength solidification of high organic mudflat marine sludge. The mudflat sludge can be effectively solidified by the SS-W-S new mineral based curing agent at the 6% dosage in three days, and the strength of solidified soil is more than three times that of PO42.5 ordinary Portland cement at the same dosage. Then it’s verified that SS-W-S mineral based curing agent has good applicability to mudflat marine sludge by large-scale application in the practical engineering. The results can provide references for the in-situ solidification of high organic mudflat marine sludge.